Frequently Asked Questions

General Information

Antibiotics

How To Take Utipro Plus

Who Can Take Utipro Plus

Other FAQ's

General Information About Utipro

When to take UtiPro Plus AF?

Utipro Plus AF is a Medical Device for the treatment of cystitis or lower uncomplicated urinary tract infections. It should be taken from the first signs of symptoms which can include a burning sensation during urination, frequent and urgent urination and pain in the lower abdomen. If symptoms do not improve after 48 hours after taking Utipro Plus AF, consult a doctor as antibiotic treatment may be required.

More severe symptoms such as flank pain (back or side pain), fever or nausea and vomiting indicate that the infection has progressed to the kidneys which requires medical attention and immediate treatment with antibiotics.

This product is not a substitute for antibiotic treatment, however, Utipro Plus AF can be taken in combination with antibiotics.

To prevent UTI recurrence, Utipro Plus AF can be used long term for 15 consecutive days each month.

HOW DOES UTIPRO PLUS AF WORK?

Utipro Plus AF is a unique and innovative treatment with a dual mode of action that works in both the bladder and the intestine.

In the bladder, Utipro Plus AF alleviates the acute symptoms of cystitis through the ingredient’s hibiscus and propolis. These act to mildly acidify the urine, creating an unfavourable environment for the bacteria to grow.

In the intestine, the ingredients xyloglucan-gelose create a film that covers the surface of the intestinal mucosa. This mechanical barrier effect can prevent attachment and growth of uropathogenic bacteria (bacteria that cause UTIs) in the intestine which reduces transmission to the urinary tract and prevents subsequent infection.

As 90% of uncomplicated UTIs originate from bacteria in the bowel, the intestine is an important therapeutic target for the prevention of UTIs. Other than continuous prophylactic antibiotic regimes, no other treatments, except for Utipro Plus AF acts at the intestinal level and has the ability to block colonization of uropathogenic bacteria (bacteria that cause UTIs).

Utipro Plus AF is the first and only non-antibiotic treatment that addresses the root cause and acts at the origin of UTIs in the intestine.

HOW LONG DOES IT TAKE TO WORK?

As expected, people experiencing symptoms of cystitis often look for quick relief. Utipro Plus AF begins to work from the onset to improve symptoms. Clinical evidence showed symptoms of cystitis improved by two thirds by day 3 of treatment. If no improvement is observed after 48 hours of initiation, consult your doctor as antibiotic treatment may be required.

Antibiotics

CAN YOU TAKE ANTIBIOTICS WHILE TAKING UTIPRO PLUS AF?

Utipro Plus AF can be taken in combination with antibiotics.

WHY SHOULD I CONSIDER NON ANTIBIOTIC TREATMENTS FOR THE MANAGEMENT OF UTIS?

The treatment of uncomplicated cystitis does not always require antibiotic treatment and in most instances will resolve without their use. Unnecessary use of antibiotics not only burdens the body but can become ineffective if taken too often.

The global rise in antibiotic resistance has led to an increase in the development of national and international clinical guidelines addressing the management of UTIs, with specific attention being given to the adoption of non-antibiotic therapies to help contain antibacterial resistance.

Dosage

WHAT IS THE RECOMMENDED DOSE OF UTIPRO PLUS AF?

Treatment (uncomplicated lower UTI)

2 capsules per day, for 5 days, taken every 12 hours.

Prevention (uncomplicated lower and upper UTIs)

1 capsule per day for 15 days, followed by a 15-day break. Treatment can be repeated in cycles.

HOW LONG CAN I USE UTIPRO PLUS AF FOR?

Utipro Plus AF is safe to use in repeated cycles. Clinical experience from patients in Europe, where the product has been present since 2014, shows good effect with long-term treatment to prevent recurrence of urinary tract infections.

Long-term treatments for up to 9 months have been done without known side effects.

WHAT IS THE DOSE FOR AN ACUTE URINARY TRACT INFECTION IF YOU GET IT DURING A PREVENTATIVE TREATMENT?

Should you get an acute urinary tract infection during dosing according to preventive treatment (i.e., 1 capsule a day) you should return to the dosing for treatment (2 capsules a day for 5 days).

In addition, one should be observant of whether symptoms such as fever, back pain nausea & vomiting occur which would indicate a kidney infection. In this case consult a doctor for further investigation and antibiotic treatment.

HOW DOES XYLOGLUCAN WORK IN THE GUT?

The xyloglucan-gelose combination act in the colon by creating a film over the intestinal mucosa. This mechanical barrier effect prevents uropathogenic bacteria (bacteria that cause UTIs) from growing in the intestine and spreading to the urinary tract, causing a UTI.

WHAT ARE E.COLI BACTERIA?

E.coli is a coliform bacterium that occurs in the intestine where it makes up a large proportion of the natural intestinal flora. If the bacterium migrates from the intestine to the bladder, it can cause infections in the urinary tract.

HOW DO PROPOLIS AND HIBISCUS WORK IN THE BLADDER?

In the bladder, hibiscus and propolis act by reducing the pH value of the urine in the bladder (mild acidification), creating an unfavourable environment for the bacteria to grow. This helps to clear the infection and improve the symptoms of a lower UTI. 

WHAT DOES THE INGREDIENT XYLOGLUCAN CONSIST OF?

Xyloglucan is a natural starch extracted from the tamarind seed.

CAN UTIPRO PLUS AF ENTER THE BLOODSTREAM?

Xyloglucan has a mechanical mechanism of action and does not affect the metabolic or physiological processes in the body.  This means that there is no uptake into the blood.

The ingredients propolis and hibiscus reach, via the blood, the kidneys and then pass on to the bladder. In the bladder, they lower the pH. The acidified environment creates an unfavourable environment for the bacteria to grow.

CAN UTIPRO PLUS AF BE TAKEN IN COMBINATION WITH MEDICINES?

Yes, the product can be taken in combination with antibiotics and other drugs. There are no known drug interactions.

DOES UTIPRO PLUS AF CONTAIN SUGAR?

Utipro Plus AF contains a very low amount of sucrose. This amount is negligible.

How to Take Utipro Plus

SHOULD THE CAPSULES BE TAKEN BEFORE, DURING OR AFTER A MEAL?

The capsule can be taken with or without food. Efficacy is not affected by food intake.

IF THE CAPSULE IS TOO BIG TO SWALLOW, CAN I BREAK OPEN IT AND TAKE IT WITH FOOD OR DRINK?

It is possible to break the capsule in the middle and empty out the contents, which is a powder. To make it easier to swallow the powder, we recommend mixing it with yoghurt or in a drink with a thicker consistency. The powder on its own can have a strong smell and taste.

Who can take Utipro Plus

CAN YOU TAKE UTIPRO PLUS AF EVEN IF YOU ARE PREGNANT?

There are no studies on the use of Utipro Plus AF in pregnant and lactating women. Even though there are no known side effects, it is recommended that the product is not used during pregnancy or breastfeeding, unless otherwise indicated by a health care professional.

CAN MEN TAKE UTIPRO PLUS AF?

The product is intended for lower uncomplicated urinary tract infections/cystitis, which is a common infection in women. Men have a much longer urethra than women, so often when men get a urinary tract infection, it is more complicated and needs to be treated by a doctor. However, it is safe for men to use the product.

IS THERE AN AGE LIMIT FOR UTIPRO PLUS AF?

The product is recommended from 18 years and up, unless otherwise indicated by a healthcare professional.

CAN YOU USE UTIPRO PLUS AF IF YOU HAVE DIABETES?

Yes, Utipro Plus AF is safe for diabetics.

CAN UTIPRO PLUS AF BE USED BY PEOPLE WITH MULTIPLE SCLEROSIS OR OTHER SIMILAR CHRONIC DISEASES AND THOSE WITH IMPAIRED KIDNEY FUNCTION?

There is no danger in taking Utipro Plus AF if you have multiple sclerosis or other chronic diseases. Even those with impaired kidney function can take it. Utipro Plus has no known contraindications, however, its use in complicated conditions or in people with serious pathologies should always be under medical supervision.

CAN YOU TAKE UTIPRO PLUS IF YOU ARE ALLERGIC, LACTOSE OR GLUTEN INTOLERANT?

If you are hypersensitive to any of the product’s ingredients: xyloglucan, gelose, propolis or hibiscus, do not take Utipro Plus AF. The product does not contain lactose or gluten.

IS UTIPRO PLUS AF SUITABLE FOR VEGETARIANS AND VEGANS?

Utipro Plus AF is suitable for vegetarians but not vegans.

Other FAQ’s for Utipro Plus

DOES UTIPRO PLUS AF HAVE INGREDIENTS BASED ON COW'S MILK?

No, the product does not contain any origin from cow’s milk.

DOES THE MUCOPROTECTANT XYLOGLUCAN IN UTIPRO PLUS AFFECT NUTRIENT ABSORPTION IN ANY WAY?

The Xyloglucan-gelose film acts to reinforce the already existing intestinal mucosa and does not affect the absorption of nutrients or drugs. 

DOES THE FILM PREVENT THE UPTAKE OF GOOD BACTERIA, FOR EXAMPLE IF YOU TAKE PROBIOTIC SUPPLEMENTS?

No, the xyloglucan-gelose film has the same properties as the intestinal mucosa and does not interfere with the functioning of the commensal bacteria or the efficacy of probiotic supplements.

WHAT DOES IT MEAN THAT UTIPRO PLUS HAS THE CLASSIFICATION MEDICAL DEVICE PRODUCT?

Utipro® Plus is classified as a medical device. This means that the product is registered in the EU, assessed and reviewed by a European Notified Body and meets the requirements set for this type of product. The studies have a high scientific evidence and are published, reviewed and approved by experts knowledgeable in the field.

HOW IS UTIPRO PLUS AF DIFFERENT TO OTHER UTI PRODUCTS lIKE D-MANNOSE OR CRANBERRY BASED PRODUCTS?

Utipro Plus AF is a unique and innovative treatment as it has a dual mode of action that works in both the bladder and the intestine.

As 90% of uncomplicated UTIs originate from bacteria in the bowel, the intestine is an important therapeutic target for the prevention of UTIs. Other than continuous prophylactic antibiotic regimes, no other treatments, except for Utipro Plus AF act at the intestinal level. 

Utipro Plus AF is the first and only non-antibiotic treatment that acts at the origin of UTIs and has the ability to block colonization of uropathogenic bacteria in the intestine (bacteria that cause UTIs).

WHERE CAN I BUY UTIPRO PLUS?

Utipro Plus AF is available in pharmacies nationwide and from the online Pamex shop at shop.pamex.com

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