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Utipro Plus Recognised by the European Association of Urology

Utipro® Plus AF: A Clinically Proven Antibiotic-Free Approach to Urinary Tract Infection Management

European Association of Urology (EAU) Guidelines on Urological Infections.1

Due to the global rise in antimicrobial resistance (AMR), there is a growing emphasis on antibiotic stewardship and more judicious prescribing practices. The European Association of Urology (EAU) and other clinical practice guidelines recommend the consideration of antibiotic-free therapies for the management of both acute and recurrent cystitis.1-5

The 2025 EAU Guidelines on Urological Infections state that…

“A combination of xyloglucan, hibiscus and propolis is effective in relieving acute cystitis symptoms and preventing recurrence“1supported by the highest level of evidence – 1a*

*LE: 1a – Evidence from systematic reviews or meta-analysis of RCTs.

Assess Recurrent UTI Risk in Women:
Check your Patients Risk Level Here

Nomogram for predicting the likelihood of recurring urinary tract infections in women.

Answer each question below. For use by Healthcare Professionals.

Bowel function(Required)
Pathogens(Required)
Hormonal status(Required)
Number of Recurring UTI*(Required)
ASB Treatment (Treatment of Asymptomatic Bacteriuria) *in the last 12 months(Required)
Number of Partners(Required)

How does Utipro® Plus AF work?

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Xyloglucan-Gelose

Xyloglucan is a mucoprotectant of plant origin.10Its fibrous composition makes it resistant to digestion.  When it arrives in the large intestine, its viscoelastic properties allow it to form a protective layer over the surface of the intestinal mucosa, reinforcing the integrity of the intestinal barrier.This reduces the adhesion of uropathogenic bacteria to the intestinal wall, which in turn reduces growth and proliferation of bacteria in the intestine.10The overall effect reduces transmission of bacteria outside of the intestine which may prevent  infection of the urinary tract.10
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Hibiscus & Propolis

Hibiscus, a type of plant and Propolis, a compound produced by bees both contain organic acids that mildly decrease urinary pH in the bladder.10Infected urine contains large amounts of nitrite. Acidification of nitrite results in the formation of nitric oxide (NO) which creates an unfavourable environment for bacterial growth, helping to eliminate bacteria and control symptoms of cystitis.10
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Why breaking the cycle of UTIs can start with your intestine?

The majority of uncomplicated UTIs originate from bacteria in the large intestine, making it an important target for the prevention of recurrent infections.10
Utipro Plus AF is currently the only non antibiotic treatment approach that effectively targets the source of infection in the intestine by creating a protective layer that reduces the growth of bacteria and their subsequent ascent into the bladder.10

Demonstrated efficacy in published clinical trials and published scientific papers for both acute and recurrent urinary tract infections.

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Reduced the use of antibiotics. 9 out of 10 patients did not require antibiotics with Utipro®10

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Improved Symptoms

Utipro® improved the symptoms associated with acute cystitis after 5 days of treatment, compared to a placebo, reducing need for antibiotic treatment.10
Utipro plus graph improves-the-symptoms-associated-with-acute-cystitis-UPDATED
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Provided relief from the onset10

 

Utipro® provided rapid relief of symptoms

  • Fast decrease in pain during urination

     

  • Fast relief from the urgency to urinate

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Significantly reduced UTI relapses after 6 months11

Utipro® reduced patient relapses of UTIs after 6 months.

Utipro graph Significantly-reduces-UTI-relapses-after-6-months-Updated
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2 Caps x 5 Days

For Acute Cystitis

From the development of the first symptoms of urinary discomfort.
Take 2 capsules per day (1 capsule every 12 hours) for 5 days.

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1 Caps x 15 Days

For Recurrent UTIs

To prevent recurrence, take 1 capsule per day for 15 consecutive days per month.
Treatment can be repeated in cycles to prevent recurrences.

If a UTI occurs during a 15 day cycle or the 15 days break.

Utipro Plus AF should be taken from the first signs of symptoms of an infection, regardless of where you are on the cycle. After 5 days of treatment with 2 capsules a day, start the cycle again and continue to take 1 capsule a day for 15 consecutive days

References

  1. Bonkat G, Bartoletti R, et al. EAU Guidelines on Urological Infections 2025. European Associa- tion of Urology; 2025. Available from: https://uroweb.org/guidelines/urological-infec- tions
  2. Betschart C, Albrich WC, et al. Guideline of the Swiss Society of Gynaecolo- gy and Obstetrics (SSGO) on acute and recurrent urinary tract infections in women, including pregnancy. Swiss Med Wkly. 2020;150:w20236.
  3. Health Service Execu- tive. Antibiotic Prescribing: Uncomplicated UTI in Adult Non-Pregnant Females. Available from: https://www.hse.ie/eng/services/list/2/gp/antibiotic-prescrib- ing/conditions-and-treatments/urinary/adult-female-uti/
  4. National Institute for Health and Care Excellence (NICE). Urinary tract infection (lower): antimicrobial prescribing. NICE guideline NG109; 2018. Available from: https://ww- w.nice.org.uk/guidance/ng109
  5. Health Service Executive. Antibiotic Prescribing: Recurrent UTI in Adult Non-Pregnant Females. Available from: https://ww- w.hse.ie/eng/services/list/2/gp/antibiotic-prescrib- ing/conditions-and-treatments/urinary/recurrent-uti-in-adult-non-pregnant-females/ Betschart C, Albrich WC, Brandner S et al. Guideline of the Swiss Society of Gynaecology and Obstetrics (SSGO) on acute and recurrent urinary tract infections in women, including pregnancy. Swiss Med Wkly. 2020;150:w20236
  6. Health Service Executive. Antibiotic Prescribing. Uncomplicated UTI in Adult Non-Pregnant Females. https://www.hse.ie/eng/services/list/2/gp/antibiotic-prescribing/conditions-and-treatments/urinary/adult-female-uti/
  7. National Institute for Health and Care Excellence. (5). Urinary tract infection(2): antimicrobial prescribing. https://www.nice.org.uk/guidance/ng109.
  8. Health Service Executive. Antibiotic Prescribing. Recurrent UTI in Adult, Non-Pregnant Females.
    https://www.hse.ie/eng/services/list/2/gp/antibiotic-prescribing/conditions-and-treatments/urinary/recurrent-uti-in-adult-non-pregnant-females/
  9. Naber KG, Bonkat G, Wagenlehner FME. The EAU and AUA/CUA/SUFU Guidelines on Recurrent Urinary Tract Infections: What is the Difference? Eur Urol. 2020 Nov;78(5):645-646.
  10. Garcia-Larrosa, A.; Alexe, O. Efficacy and Safety of a Medical Device versus Placebo in the Early Treatment of Patients with Symptoms of Urinary Tract Infection: A Randomized Controlled Trial. Clin. Microbiol. 2016, 5, 1
  11. Salvatorelli, N.; Garcia-Larrosa, A.; Allegrini, A.; Pavone, D. A New Approach to the Treatment of Uncomplicated Cystitis: Results of a Randomized Placebo-Controlled Clinical Trial. Urol. Int. 2016, 97, 347–351
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