Healthcare Professionals

Non-antibiotic strategies for recurrent UTIs

This webinar features an expert panel discussion on recurrent UTI management, highlighting current challenges, guideline recommendations and the role of non-antibiotic strategies in supporting antimicrobial stewardship.

The session explores Utipro® Plus AF, an exciting antibiotic-sparing option, and discusses its clinical rationale, evidence base and application in practice.

Speakers include:

Prof. Tommaso Cai | Head of Urology, Santa Maria del Carmine Hospital, Rovereto, Italy;
Chair: Ms Jhumar Pati | Consultant Urological Surgeon, Homerton University Hospital NHS Foundation Trust, London

Assess Recurrent UTI Risk in Women:
Check your Patients Risk Level Here

Nomogram for predicting the likelihood of recurring urinary tract infections in women.

Answer each question below. For use by Healthcare Professionals.

How does Utipro^® Plus AF work?

Xyloglucan-Gelose

Xyloglucan is a mucoprotectant of plant origin.¹⁰Its fibrous composition makes it resistant to digestion. When it arrives in the large intestine, its viscoelastic properties allow it to form a protective layer over the surface of the intestinal mucosa, reinforcing the integrity of the intestinal barrier.This reduces the adhesion of uropathogenic bacteria to the intestinal wall, which in turn reduces growth and proliferation of bacteria in the intestine.¹⁰The overall effect reduces transmission of bacteria outside of the intestine which may prevent infection of the urinary tract.¹⁰

Hibiscus & Propolis

Hibiscus, a type of plant and Propolis, a compound produced by bees both contain organic acids that mildly decrease urinary pH in the bladder.10Infected urine contains large amounts of nitrite. Acidification of nitrite results in the formation of nitric oxide (NO) which creates an unfavourable environment for bacterial growth, helping to eliminate bacteria and control symptoms of cystitis.10

Why breaking the cycle of UTIs can start with your intestine?

The majority of uncomplicated UTIs originate from bacteria in the large intestine, making it an important target for the prevention of recurrent infections.¹⁰

Utipro Plus AF is currently the only non antibiotic treatment approach that effectively targets the source of infection in the intestine by creating a protective layer that reduces the growth of bacteria and their subsequent ascent into the bladder.¹⁰

Demonstrated efficacy in published clinical trials and published scientific papers for both acute and recurrent urinary tract infections.

2 Caps x 5 Days

For Acute Cystitis

From the development of the first symptoms of urinary discomfort.
Take 2 capsules per day (1 capsule every 12 hours) for 5 days.

1 Caps x 15 Days

For Recurrent UTIs

To prevent recurrence, take 1 capsule per day for 15 consecutive days per month.
Treatment can be repeated in cycles to prevent recurrences.

If a UTI occurs during a 15 day cycle or the 15 days break.

Utipro Plus AF should be taken from the first signs of symptoms of an infection, regardless of where you are on the cycle. After 5 days of treatment with 2 capsules a day, start the cycle again and continue to take 1 capsule a day for 15 consecutive days

Key Clinical Publications

Click the links below to learn more!

Kostev, K.; Cai, T.
Cystitis and Utipro® Plus: Real-World Evidence.
Healthcare (Basel). 2023;11(18):2564.
DOI: https://doi.org/10.3390/healthcare11182564
Cai, T.; Anceschi, U.; Tamanini, I.; et al.
Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis.
Antibiotics (Basel). 2021;11(1):14.
DOI: https://doi.org/10.3390/antibiotics11010014
Garcia-Larrosa, A.; Alexe, O.
Efficacy and Safety of a Medical Device versus Placebo in the Early Treatment of Patients with Symptoms of Urinary Tract Infection: A Randomized Controlled Trial.
Clin Microbiol. 2016;5:1
DOI:10.4172/2327-5073.1000233
Salvatorelli, N.; Garcia-Larrosa, A.; Allegrini, A.; Pavone, D.
A New Approach to the Treatment of Uncomplicated Cystitis: Results of a Randomized Placebo-Controlled Clinical Trial.
Urologia Internationalis. 2016;97:347–351
DOI: https://doi.org/10.1159/000445326
Costache, R.C.; Novac, B.; Bardan, T.R.; et al.
Xyloglucan + gelose combination versus placebo as adjuvant therapy to first-line antimicrobials for uncomplicated urinary tract infection in adults.
Urologia Internationalis. 2019;102:468–475
DOI: https://doi.org/10.1159/000497106
Cai, T.; Tamanini, I.; Cocci, A.; et al.
Xyloglucan, hibiscus and propolis to reduce symptoms and antibiotics use in recurrent UTIs: A prospective study.
Future Microbiology. 2019;14:1013–1021
DOI: https://doi.org/10.2217/fmb-2019-0145
Ortega, P.; Benito, E.; Berrocal, F.
Clinical Experience with a Medical Device Containing Xyloglucan, Hibiscus, and Propolis for the Control of Acute Uncomplicated UTI-like Symptoms.
Uro. 2022;2:245–253
DOI: https://doi.org/10.3390/uro2040027
Cai, T.; Konstantinidis, C.; Ward, S.
A non-pharmacological approach to the treatment of urinary tract infections: case reports with Utipro® Plus.
Drugs in Context. 2021;10:2021-2-2
DOI: https://doi.org/10.7573/dic.2021-2-2

Utipro^® Plus AF: A Clinically Proven Antibiotic-Free Approach to Urinary Tract Infection Management

European Association of Urology (EAU) Guidelines on Urological Infections.¹

The 2025 EAU Guidelines on Urological Infections state that…

Non-antibiotic strategies for recurrent UTIs

Assess Recurrent UTI Risk in Women:
Check your Patients Risk Level Here