About Utipro® Plus AF

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Utipro® Plus AF is a Class IIa Medical Device for the control and prevention of uncomplicated
urinary tract infections caused by pathogens such as E. coli and other gram (-) bacteria
normally involved in the etiology of urological infections.

Utipro® Plus AF is safe, well tolerated and reduces the bacteriological and symptomatic
parameters in adults, with uncomplicated UTIs.1

An Innovative Approach to Rationalise the Antimicrobial Treatment (Antibiotics).1

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9/10 patients with uncomplicated cystitis did
not require an antibiotic with Utipro®2

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E. coli that reside in the bowel are responsible for the majority of cases of uncomplicated urinary tract infections (UTIs).3

When these bacteria leave the bowel, they can swiftly invade the bladder causing inflammation of the bladder wall.4

Women are particularly affected by a urinary tract infections (UTIs) due to their anatomy. A woman has a shorter urethra than a man, which shortens the distance that bacteria have to travel to reach the bladder.


In addition to this, the close proximity of the anus to the urethra in women also facilitates the development of urinary tract infections (UTIs).4

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How does Utipro® Plus AF work?

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The Xyloglucan-Gelose creates a film that covers the surface of the intestinal mucosa. This effect can prevent adhesion and growth of bacteria reducing transmission to the urinary tract.2
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The Hibiscus and Propolis mildly acidify urine, helping to
eliminate E. coli and control symptoms of UTIs, including:
  • Painful urination
  • Frequent urination
  • Urgent urination
  • Bladder tenderness or pain2
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The use of mucoprotectors improves the symptoms associated with acute cystitis after 5 days of treatment, compared to placebo, reducing need for antibiotic treatment.2

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2 Caps x 5 Days

For Acute Cystitis

From the development of the first symptoms of urinary discomfort. Take 2 capsules per day (1 capsule every 12 hours) for 5 days.5
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1 Caps x 15 Days

For Recurrent UTIs

To prevent recurrence, take 1 capsule per day for 15 consecutive days per month.5
Treatment can be repeated in cycles to prevent recurrences.6

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  1. Costache RD et al. Xyloglucan + Gelose Combination versus Placebo as Adjuvant Therapy to First-Line Antimicrobials for Uncomplicated Urinary Tract Infection in Adults – Urologia Internationalis 2019;102:468–475.
  2. Garcia-Larossa A, Alexe O.Efficacy and safety of a medical device versus placebo in the early treatment of patients with symptoms of a urinary tract infection: a randomised controlled trial . Clin. Microbiol. 5,1 (2016).
  3. Flores –Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary Tract Infections: epidemiology, mechanisms of action and treatment options. Nat Rev Microbiol. 2015 May;13(5):269-84.
  4. Guglietta A. Recurrent Urinary tract infections in women: risk factors, etiology, pathogenesis and prophylaxis. Future Microbiol . 2017 Feb; 12 (3).
  5. Utipro Plus AF Product Information Leaflet Rev.02.01.09.2019
  6. T Cai et al. Xyloglucan, hibiscus and propolis to reduce symptoms and antibiotics use in recurrent UTIs: a prospective study – Future Microbiology, 2019; 14:1013-1021.

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